Story 3 – Discussion (part 2)

The second part of Story 3 explores more aspects of the DNA molecule both when used as a message and when used to create new organisms. Also, we take a look into biological processes that are defined in terms of positive and negative feedback loops.Here are some questions you might want to discuss with your kids:

Q: What happens when we change a sequence in the DNA or we start messing with the DNA strand and we cut and paste pieces from other DNA strands into it?
A: We get an engineered DNA strand that may or may not exist in nature. The change can be as small as changing the color of your hair or as big as transforming you into a new type of organism altogether, like a mutant.

Q: What do you think is Daena’s best quality that makes her a great DNA detective?
A: First, she knows her biology. Second, she is inventive and tries to find solutions based on her knowledge. Third, her solutions are not complicated. They are simple and they work.

Q: How did Daena beat the Ugga Ugga virus at the end?
A: First she changed the DNA of the Ugga Ugga virus to create a stronger (and not evil) virus, the Gaga Gaga virus, and then used the Gaga Gaga virus to kill the Ugga Ugga virus by creating a negative-positive feedback loop.

Q: How does a negative feedback loop work? Can you show an example of a negative feedback loop at your home?
A: A negative feedback loop works by regulating the amount of something. The more of the “something” we have, the feedback loop will try to make this “something” less. The less of the “something” we have, the feedback loop will try to make this “something” more.
This is for example how we maintain temperature in a house using a thermostat. In this case the “something” is the “heat”. The more heat we have, the thermostat will tell the A/C to blow cool air into the house to bring down the heat.

I hope we learned something useful today,
Dr. Techniko

Story 3.5 – Daena the DNA Detective And The Ugga Ugga Virus (The Final Battle)

“We need to catch one of these viruses and …” but before Daena could form a plan, the big hungry monkey head with the twisted sharp teeth started approaching them.

“DannyBot, this Ugga Ugga seems to take an interest in us. We should head back and reevaluate. I’m not in the mood for drama.”

They turned around but another Ugga Ugga virus blocked the exit.

“Dannybot, without being too dramatic I think we are …”

The virus zoomed at them, mouth wide open.

“DOOMED!”

But the next instant the virus was caught by a lasso made of DNA coming out of … DannyBot’s body. The lasso wrapped the virus around the mouth and body tight as a squeezing tentacle. Once Daena realized they were safe she headed to the exit, DannyBot and their new prisoner behind her.

“If I were not under the shock of a near-death experience, I would be impressed. Dannybot, I didn’t know you could do that.”

“It’s quite a basic function I’ve been designed for. My lasso makes bonds at the molecular level with the object so the object is unlikely to escape,” said DannyBot as if he had lassoed a harmless-looking water molecule.

They dragged the Ugga Ugga prisoner to the closest White Cell headquarters, at the tonsils.

DannyBot constructed a message from DNA, asking for permission to see the Warden and gave it to the nearest guard. It felt like a lifetime until the gate opened. When they found the Warden he was floating around his office, eating random proteins. He looked quite well-fed in fact.

“What can I do you for, Miss Daena?” asked the Warden.

“First of all, it’s DNA Detective Daena. Second, you ‘ve been infected by a genetically engineered virus. As proof, I brought a sample right here into your office.”

“He don’t look so dangerous to me. Just a monkey face. We ‘ll take the prisoner from here. Off you go now.”

The guards escorted them out of the headquarters.

“I assume the mission has been completed. Shall I set course for the extraction point?” asked DannyBot.

“Nothing would cheer me up more, but I have a depressing feeling about this. Let’s just wait out here. How much time left?”

“There are three hours left to total infection.”

It felt like forever until finally the gates opened. At first, it looked like the Warden coming out of the gates. But as he moved out of the gate and into the light, he didn’t look as white as before. He looked dark and ugly and had twisted sharp teeth. Like an Ugga Ugga virus!

The two guards at the gates tried to swim away, but before they could escape, a hoard of hungry monkey faces stormed out of the gates and brought an end to them.

“Eat my children. Eat and multiply!” said the Warden as the monkey heads swarmed the area. Then his eyes fell on Daena. He started eating his way towards her in a steady pace.

“This doesn’t look good. DannyBot, let’s hide before more of these monsters realize we are here!”

“Don’t go Missy. Come and feed me,” said the Warden, and then gulped down a couple of his children.

They zoomed away from the tonsils and went into hiding behind the nose. “The Warden might be slow, but his children are multiplying. How much time left, DannyBot?”

“We have entered the last hour.”

Daena sighed. This was all very stressful. She wished she was back inside her vial even if it was not near a window, even if had to look at the same sticker all day:

-The recipe of life and death lies in the DNA-
The recipe lies in the DNA, she thought. Her mind drifted off to her first class at the detective academy and the principle-of-life rule they all had to memorize:

The DNA recipe is written with 4 letters.

What are they?

T, G, C and A.

And when DNA splits in two

Each half is called RNA

And every letter T is replaced by a U.

“That’s it!” Daena jumped with excitement. “I figured out how to kill the Ugga Ugga virus! The recipe of life and death lies in the DNA. Get it, DannyBot?”

DannyBot blinked.

Daena sighed. “Ugga Ugga’s DNA contains the recipe for making an Ugga Ugga virus. It’s like when you read a message written in DNA language using the T, G, C and A 4-letter alphabet. Only the message is also the recipe. Do you see?”

“I don’t see how this helps us defeat the Ugga Ugga virus,” said DannyBot.

“Well, here is the missing puzzle piece. DNA doesn’t make the Ugga Ugga directly. It has to first split into two RNA strands, and in the RNA alphabet T is replaced by a U.”

“I don’t see how this helps us defeat the Ugga Ugga virus,” repeated DannyBot.

“Don’t you get it? What’s the code name of the Ugga Ugga virus in RNA alphabet?” said Daena as if explaining the concept to a hydrogen atom.

“U-G-G-A-U-G-G-A,” said DannyBot.

“Can you search your data for the U-G-G-A-U-G-G-A sequence in the Ugga Ugga virus’s RNA?”

A few moments later DannyBot said “I searched. I found the pattern.”

“Great. I want you to synthesize the same RNA strand but replace the U-G-G-A-U-G-G-A pattern with the G-A-G-A-G-A-G-A pattern.”

DannyBot synthesized the mutated Ugga Ugga virus strand. One by one he glued together A’s and C’s and G’s and U’s until he had a full RNA strand.

“The sequence is ready. But I don’t see how this helps us defeat the Ugga Ugga virus,” said DannyBot.

Daena closed her eyes. She wished she had a hydrogen atom for a partner.

“Because if we get the Warden to eat this mutated Ugga Ugga strand, then he will use the wrong recipe to make children. His children will be Gaga Gaga viruses instead. Then the Gaga Gaga viruses can fight the Ugga Ugga viruses. I think it’s time to pay a visit to these depressing monkey faces.”

They zoomed back to the tonsils with the Gaga Gaga strand in hand. The Warden eyed them with a hungry look.

“Bring them to me, my children!”

Before Daena and DannyBot realized what was going on, they found themselves wrapped by DNA lassos from a bunch of Ugga Ugga viruses.

“My calculations tell me he means to eat us,” said DannyBot.

“You depress me.”

“Miss Daena. Why so gloomy? You should be happy, because you’ll make a tasty snack,” said the Warden and opened his mouth.

“Wait, wait! You don’t want to eat me like that. I’m more tasty if you eat this first as an appetizer,” Daena waved the Gaga Gaga virus strand in his face.

“You ‘re a real lady,” said the Warden and he gulped down the Gaga Gaga strand. He burped and said “Missy, that was really yummy. Remind me to get the recipe after I eat you.”

He came closer to Daena, opened his mouth and was about to close it over her head, but instead he grew and grew and grew until he… burst and a bunch of Gaga Gaga viruses came out of his body.

Soon a war begun between the Ugga Ugga and the Gaga Gaga as they started eating each other. Whenever an Ugga Ugga ate a Gaga Gaga, it gave birth to Gaga Gagas.

But, whenever a Gaga Gaga ate an Ugga Ugga, it gave birth to Gaga Gagas. Soon the Ugga Ugga’s were wiped out.

“He should not have eaten the Gaga Gaga strand before checking it, but I didn’t think it was a good idea to tell him,” said DannyBot.

“DannyBot, you are learning. Yet you still have ways to go to before you understand the genius of my scheme that killed the Ugga Ugga virus.”

“There was nothing to understand. It was based on a pair of positive and negative feedback loops. It is quite a very elementary and primitive principle of life,” said DannyBot.

“You really depress me.”

Will school teachers be replaced by intelligent portable software?

I’ve been reading lately about new approaches to teach children science and technology through storytelling via the use of specialized software and portable devices. The most notable effort I’ve come across is Alan Kay’s Viewpoints Research Institute which is integrated with the One Laptop Per Child project. The idea is that through the use of media and the integration of activities in one interface, children can understand complex concepts in science.

Another tool I came across is called Processing. Even though this software is not really targeted for children, it serves the same purpose: teach complex concepts through an intuitive user interface. Maybe in the future it could be tweaked for teaching kids how to write software.

Given the highly sophisticated educational software out there and the web’s ability to find knowledge fast, it’s fair to ask why would a teacher-in-school setting be necessary in educating our children in the future? In fact there are examples, where teachers start being replaced by devices running educational software.

An approach by Microsoft research relies on a multi-point mouse interface and off-the-shelf PC equipment to allow children in developing countries to teach themselves without the need for a teacher.

A start-up company called Knewton uses adaptive algorithms to coach students on standardized tests (e.g., SAT) in a personalized fashion by “understanding” their skill level. In addition, online services like MIT’s OpenCourseWare, teach university-level classes through rich-media content from the comfort of one’s home.

At the same time, the current generation of portable devices (iPad, iPhone, Android tablets) expose simple to use interfaces. Simple enough for children to use on a daily basis. So children could carry them around, meet with their friends and play and learn together. Not only that, but there are already games available that provide alternatives to learning how to read or count.

So, it won’t be long before schools have children carry around portable devices through which they enhance their learning. In fact, some schools have already started doing this.

So the obvious question is: will school teachers be entirely replaced? After all, intelligent portable software and a great user interface provide a powerful interactive storytelling medium that can not only capture the attention of a child, but also convey very sophisticated concepts that a teacher and a blackboard cannot.

On the other hand, after reading “Work Hard, Be Nice”, I see how much power an effective teacher can have in a child’s life. The passion and persistence of the founders of the KIPP schools is hard to replicate using software running on a personal portable device. The teachers made each class a ritual and enforced a “no shortcuts” culture in their schools by confronting students in person. Even unmotivated students responded positively. An iPad can’t do that.

What do you as current or future parents, teachers and educators think on this matter? I’ve created the following poll to pick your brains.

I hope we learned something useful today,

Dr. Techniko

Story 2 – Discussion

The story of the Dragon’s Treasure Makeover aims to teach both a problem-solving skill and a technical skill.

First, the problem-solving skill is “try to understand the nature of a problem before you attempt a solution”. Imagine your printer is not working and you say “It worked fine yesterday. What happened? It broke. I’ll call support,” when in reality someone by mistake pulled the printer’s plug.   In the story, all three wizards use the Spellopedia Magica, but only Thinkalot picks a useful spell out of the book. That’s because he asked questions in order to understand the true nature of the Dragon’s problem. Understanding the nature of a problem is most of the time harder than coming up with a solution. It’s a skill that takes time to acquire, but it’s invaluable. If your children are stuck on a problem you can teach them by saying:

“Understand the problem and you ‘re more than half way towards the solution.”

Second, the technical skill is “if you organize things based on an identifier then it’s faster to search through them”. In this information-loaded age, information management is a great skill to acquire, so this story will provide a good discussion framework for you and your children on this topic.

I’d be interested to hear your opinion or reactions of your children on these topics.

Here are some comprehension questions you might want to ask:

1. If you were a Dragon which wizard would you hire and why?
(Thinkalot because he would try to understand my problem before he cast a spell.)

2. If you were the Dragon how would you change your ad in the Magic Network to make more clear what your problem was?
(“looking for wizard to help with search of treasure. I would like to be able to find any item in my treasure in about one day. I don’t want to lose any of my treasure” etc. The goal is to write a more specific ad.)

3. Thinkalot’s solution splits the treasure based on the first letter of each item. That splits the treasure in 26 piles. What if half of the treasure items started with “A”? It would take the Dragon half a month instead of a day to search for an item starting with “A”. So Thinkalot would be in trouble! Can you help Thinkalot find a better solution before the Dragon finds out?
(One way to solve this is to split the “A” pile into 26 piles using the second letter and so on. There are even better solutions if you are creative with your sorting criteria. I’d be interested to hear what your children can think of!)

I hope we learned something useful today,
Dr. Techniko